I bet there is gonna be one final DMC chronologically after DMC2, but propably the last one, kind of Endgame. Capcom is not in a hurry to go there anytime soon. There are more DMCs to come and the only time this can happen is between 4 and 2. No DMC after DMC2 would be fun regarding Dante's character. So maybe one game for an all guns blazing ending and that's it. For the time being Dante will continue to smile ironically and Nero will grow mature.

... And she cradles me down into sleep
Still I miss her so and for more I weep
And she gives me death yet i'm alive
raving eternally, on her I thrive..
... And she buries me down far too deep
Yet six-feet high and gives me bliss to keep
and she abuses me yet I abide
She's in demand, my hunger I cannot hide..
Her name's Jez..