Goatlings, Blood Goats, and Abyss Goats
Goat-like demons. These guys are tough early on in the game. They are able to fly, and they are just as dangerous in the air as they are on the ground. When in the air, these enemies have the ability to do a charged up, homing energy attack. As soon as you see them start to glow with yellow energy, start dodging, or fire at them in hopes that you'll knock them out of the sky or stun them.

They can also cause blue energy to come up out of the floor. Quick dodging is the only way to avoid getting injured, and you must use your firearms to make them stop. While on the ground, they are able to do an overhead slash, or a side slash. If you hit them with your sword, you should be able to stun them, and get in a few more attacks. Always try to keep the Goatlings on the ground.

If you are up against more than one at a time, dodge out of the way after every two or three hits, and start slashing again. Try to use stingers and high times to separate them, and then take them on one on one. If you're Dante, use the shotgun when they are in the air to bring them down.

Infested Tank 
Only Lucia fights this as a boss, Dante fights it as a sub-boss. This tank can fire missiles or a flame thrower attack from its turret. If you jump up on top of it, then it will fire its machine gun at you. Those are its only attacks. These guys are pretty easy as long as you are only fighting one of them. If it is one on one, just dodge until you are behind it and then start attacking. When the turret turns toward you, just dodge until you are behind it again. If you are fighting more than one, just be sure to dodge after every combo attack.

Infested Chopper 
Only Dante fights this boss. You'll have limited moving space, so be sure not to fall off of the building. The chopper will almost always be firing its machine gun at you. If you see it coming at you, dodge out of the way. It will also fire homing rockets at you, which you will have to avoid, or shoot down with your guns. The best way to kill him is to constantly keep shooting him with Ebony and Ivory while moving with the joystick. If the chopper comes directly over you, then you should jump up and do a sword combo. When your DT is full, use it and start shooting at the chopper. Finally, don't jump up to high when you are near the chopper, or its blades will injure you. 

Friki & Geri 
These wolves always travel in pairs. They will always be moving around the room, and if you get in front of them, then you will get hit. Sometimes they stop and howl. This means that they are going to do a plowing attack forward. Move around behind them and start slashing. If you are near them, then you should slash them, but if your hits don't connect then you should bring out the shotgun and start firing.

Savage Golem 
These guys are annoying because they will heal themselves if you stop attacking them. If it looks like they are hugging themselves, then dodge away because spikes will come from their bodies. They can also cause spikes to come out of the floor. Rarely, they will spit poison at you.

Stay at a distance, and blast them with your shotgun or your Throwing Daggers until their health is in the red. Then move in and attack with your sword. Don't stop until they are dead, or they will run off and regenerate.