Plutonian & Tartarussian
This is Lucia's first boss, and he has annoying giant swinging maces for hands. Most of the time he'll just swing these at you and try to hit you, nothing some quick dodging can't handle. If he raises both of them over his head, then that means that he is going to swing them down in your direction. If you see him bring one of them down beside him, then that means that he is going to use it like a bowling ball. Getting to close to him will cause him to hit you with a horizontal swing.

Standing still is a definite No-No for this fight. Basically just jump or dodge out of the way whenever you see him start to move one of his arms. Wait till he attacks before you move in for a few quick slashes, and then quickly move away or you'll be hit. When your DT gauge is full, move in and begin attacking in DT mode. He will not be unable to attack you while you are attacking him in DT mode.

Later, when you fight him again and when Dante fights him, their will be some Agonofinis in the room, and lasers will shoot out of the wall. Just dodge to avoid the lasers.

Orangguerra
A large guerrilla that attacks Dante in the Train station. This guy can be kinda tough if you don't stay on the move. His main attack happens when he starts climbing on the ceiling. He'll climb over to you, and attempt to jump down on you. He can also drop glass down on you if you are directly under him. To prevent this, quickly jump up and strike him down with your sword. His other attacks are an overhead swing, and a horizontal swing. To avoid these, simply dodge behind him, and strike him with your sword. To beat him, just keep dodging and slashing until your devil trigger gauge is filled. Then DT, and get up in his face for some up close and personal slashing. As long as you are DT'd your swings should stun him so that he cannot attack you. Use your guns only while he is on the ceiling, or while you are jumping. If you just stand still and shoot, then you are going to get hit. His last attack, which he rarely uses, is a clear, energy shot that comes out of his mouth. If he stops moving, then he is probably going to use it. Just dodge if you have time to, this move is hard to dodge if you are up close to him.

Later when you fight him, he will be a little easier because he won't be able to jump up to the ceiling. When Lucia fights him, Follow the same strategy, but only use your throwing knives if you have to. They are too slow and too weak. It's much easier to just alternate between dodging and hitting until your DT maxes up, then let loose.

Jokatguin
This boss has four tentacles, which it uses to attack you. If the tentacle starts to swoop along the bottom, just jump out of the way. If one of the tentacles goes up inside its body, then it is going to shoot out, and you should dodge to avoid it. The only other attacks he has, is a poisonous spray that it can shoot out, or surround its body with. Also, if you attack it too much, it will generate a temporary force field to knock you back.

The best way to attack it is to constantly shoot at it while you are dodging its tentacles. When one of the tentacles takes enough damage, it will be stunned and it will drop its poison cloud. Now you should jump in and start attacking while DTed if possible. Don't attack for too long however, as its poison cloud will be back just as soon as it regenerates its limbs. Repeat this, and it won't take too long to die. As long as you stay on the move, you won't take too much damage. An easier way to fill your DT gauge is to attack his tentacles with your sword. Just be sure not to stand around them too long.

Nefasturris and Nefascapitis 
This boss just looks intimidating, he's actually a piece of cake. For the first part of the battle, your shotgun will be your best friend. Just constantly stay shooting him to whittle away his life. When you get the chance, DT and fly over to him so that you can attack him. His main attack is a giant laser that he shoots out of his mouth. The best way to avoid this is simply to jump over it when it comes your way. Sometimes it surrounds itself with bats so that you can't get close to it. Just wait for them to leave, or shoot them if you have to. The attack to watch out for is his multi laser attack. This one is tough to dodge, but if you see him getting ready to do it, just start tapping the dodge button.

After you defeat it, you will have to fight its disembodied head. The head will fly around shooting easily dodged energy at you. Shoot it with your shotgun while it is doing this. When it lands on the ground, dodge around until you are behind it, or you will be hit by the multi laser attack. DT when you are behind it, and start attacking it with your sword. After a while, it will start shooting horizontal and vertical electricity at you. Jump over the horizontal ones and dodge around the vertical ones. 

Furiataurus
Furiataurus: Only Dante fights this flame-based boss. Equip your offence heart and your quick heart for this fight. This boss has a charging attack which is just barely dodge able. If you can dodge it though, you will be in prime position to start attacking his backside. Don't attack for too long though, or he will turn around and swing his scepter in front of him to hit you. Another attack he has is when he jumps up into the air and slams into the ground, causing a ring of fire to encircle him.

If you see him start to jump up, jump clear of the ring, and start shooting him with your shotgun. Sometimes he'll start spraying fire out of his mouth, just dodge out of the way and start attacking him to avoid this. Sometimes, he will wave his arm around and cause the ground around him to catch fire. You will know that this is coming when the ground turns orange. He will then start swinging his staff around and try to suck you into the fire. Just run in the opposite direction to avoid this. Once your DT gauge is full, start attacking him with your sword, and you should be able to stun him so that he can't attack you while you are hitting him.

Nochpteran and Larva 
A giant moth and his babies. The moth doesn't really have any attacks, but he does have the ability to lay Larva on the ground, and they will attack you. The Larva will run straight at you and attempt to swallow you. If this happens, start mashing buttons, and Dante will rip his way out of the Larva, killing them instantly. The Larva can also come up out of the ground Tremors style and hurt you.

This is the best time to attack them if you are able to dodge out of the way. When you are fighting the Larva, just stay in the air, and always do a downward slash to hurt them. Your first priority however, should be to take care of the moth. You'll need the shotgun or the Throwing Daggers for this and the Aerial Heart. Jump up in the air, and blast him, then slash down or shoot the larva to build your Devil gauge. When it is full, DT and fly up towards the moth. Now start shooting and its health should dwindle pretty fast. If you manage to kill one of the Larva, the moth will fly down to lay another one. This is the only time that you can hit it with your sword. When the moth is dead, you will have to fight 6 Larva before the fight ends. Stay in the air, and use the tactics that I have given you to kill them. Use your DT whenever possible, and start slashing them. Or you could just let them swallow you and then rip them apart if you have allot of health. 

Tateobesu 
Only Lucia fights this boss, and she fights him underwater. He has the power to turn himself invisible, and while you wont be able to target him, you can still see him pretty well. The best thing to do when this happens is to just fire your bow gun in his general direction.

It will try to hit you with its tail while it is invisible, so just swim away when you see his tail turn white. When he reappears, he will try to charge you and bite you. Stop shooting and swim up as fast as you can, if done successful, he will miss you and you will be able to shoot him. Whenever you can, DT and start shooting him to make the fight go by much quicker. The best time to DT is whenever you have just dodged one of his charges.

Bolverk with Friki & Geri 
Only Dante fights this boss. Equip the quick heart and the offence heart for this battle. The main problem you will have is that Dante constantly locks on to the wolves and not Bolverk. You may want to concentrate all of your attacks on the wolves until they are dead. Never stand still during this fight, you should always be dodging unless you are attacking the boss. This boss has several damaging attacks. He is able to make his spear 10 times longer, and then slash at you with it. He only does this if you shoot him, so using guns are out of the question. He can also charge across the room and plow into you. This move is hard to dodge because of the bad camera angles.

Sometimes he will make energy come out of the floor in front of him, so dodge if the floor turns black. He can do an overhead slash, a side slash, and a multi stab with his sword, which are all easily avoided as long as you stay behind him. The best tactic is to constantly hit him with the Vendetta. If you accidentally target one of the wolves, dodge until you are back behind Bolverk. If you are hitting him, then normally he can't hit you. DT whenever possible to do massive amounts of damage with your sword. The only difference between the first and second battle is the size of the rooms. The second battle takes place in a very confined room, which makes this boss extra difficult. 

Arius 
He is actually pretty easy. His main attack is his gun, which does very little damage. He can also cause spikes to come out of the floor, and sometimes cause Dante to be sucked into a portal and thrown across the room.

The problem is that he summons other enemies to attack you while you are fighting him. In the first fight, he summons Jomothumsira and Blood Goats, and in the second fight he summons Jomothumsira and Lucias. The Lucias are the hardest because they can do multiple slashes, and the enemies numbers may overwhelm you. Try not to target them when you are fighting. If Arius teleports himself to another side of the room, use your sub machineguns or Throwing Daggers to blast him while you are walking over there. If you are next to him, then just start slashing with your sword to take away allot of his life. DT whenever possible to do massive damage. 

Phantom 
Phantom is back and he has basically the same moves as last time. If you get too close to Phantom's mouth, he will hit you with his claws, or impale you with his tail. He also has a jump attack where he will try to crush you. Just start dodging to avoid this. If Phantom sticks his head into the ground, start running because 3 or 4 lava columns will come up out of the ground.

When Phantom's mouth starts to glow, dodge behind him because he is going to shoot a fireball. If he shoots a fire ball into the air, then start running because it is going to crash back down. Equip the quick heart and the offence heart for this fight, and your sub machineguns or the Throwing Daggers. Shoot Phantom if you are far away from him, or whenever you are in the air. Slash at his head one or two times, but quickly dodge out of the way or you will be hit. DT when you can, and go up to his mouth and slash until your gauge runs dry. He should die after 2 or 3 DTs. 

Trismagia 
This boss has 2 forms. One where he splits into 3 different elemental heads (Fire, Ice, and Lightning), and one where he is just one big skull. The combined head only has one attack where he sends a giant homing blast after you. This move is hard to dodge, but just start dodging when you see the 3 circles form.

The fire head can send small homing blasts after you which you must dodge to avoid. The Lightning head will send two spheres after you that shoot lightning. Once again just dodge them. The Ice head can shoot ice at you which is easily dodged, or it will rain ice spikes down on you, which will miss you as long as you are not under their shadows. All 3 heads will come at you one at a time and hit you with some kind of elemental blast. Start dodging and try to get behind them. If they miss you, then this is the only time that you can use your swords on them. Any other time, you should be blasting them with Sub machineguns or Throwing Daggers. When the heads form one skull, DT and start firing your weapons at him to do the most damage. You should be able to build up your DT while you are fighting the 3 smaller heads. 

Argosax the Chaos 
Argosax the Chaos: You might wanna get a drink or something for this one, it's gonna be a long summary. Notice that there are several green orbs on the outside of the arena. You'll start off in front of Nefasturis who uses his giant ray attack, and his multi ray attack. Jump over the giant ray, and dodge to the side of the multi ray one.

Use your Submachine guns to damage him, and just stay as far back as possible so that you can see when to dodge his attacks. Move to your right to fight Griffon. Don't stand directly in front of him or you will be hit by several vertical and horizontal lightning attacks. Stay to the outside, DT, and blast him with your guns. Dodge any of his attacks with the Circle button, and keep on firing with the Subs if you run out of DT. Next is Furiataurus. He attacks with a blast of fire from his mouth. Don't go up and slash him or he will hit you with his hammer. You cannot blast him until he is shooting fire, so stand as far away as possible and to the side. Roll into his view and quickly roll back out again when he starts firing. Blast him with your rocket launcher until he moves the hammer back in front of him. Next is Jokatguin. He will swing his tentacle back and forth, or he will shoot it out at you. DT, and start slashing him to kill him quickly. Next is Orangguerra. If you get to close to him, he will pick you up and throw you down. If you stand far away from him, he will fire balls of energy at you. Whenever you can, DT and start slashing at his head to stop his attacks. If you run out of juice, stand as far back as possible, and alternate between dodging his energy blasts and shooting him with your sub machineguns. Save the Phantom for last because he can boost up your DT gauge. Run up to his head and start slashing until he sticks his head under ground or his mouth lights up. When this happens, start running around to avoid his attacks, and then go back up and start slashing again. Be sure to get any of the green orbs that you left around if you need them, you might not be able to once the next fight starts.
 
The Despair Embodied 
This guy is almost impossible to fight because he is faster than you are even when you are in DT. If this is your first time through, then you will probably need a Vital Star and a Devil Star. Fighting behind him doesn't work because he can hit you with a 360 slash. He also runs forward and slams into you, or does an overhead slash if you are in front of him. If you jump into the air, then he will follow you up and hit you with his wings. If he starts flying around in the air, shoot him with your subs. He will then start to shine like a rainbow. This is your cue to dodge like there's no tomorrow and you might not get hit by either the energy rain, or the homing missiles. If he's on the ground, try your best to hit him with Vendetta and then quickly dodge out of the way so that you can hit him again.

The only time you'll really be able to do anything is when your DTed. Have the Offence Heart equipped, and start slashing away or shooting him if he is in the air. It shouldn't take more than 2 Dts. I hope you can survive long enough to fill up your gauge 2 times. One thing this boss likes to do is to teleport behind you while you are attacking him, and then hit you a couple of times. You can use this against him if you have just the right timing. Go up to him but Don't attack. He will teleport, and you should immediately dodge until you are behind him, you can now hit him with a quick 3 hit combo. He will teleport again, and you should repeat the procedure. If done correctly, Despair will never lay a hand on you. 

Possessed Arius 
He will often attempt a running charge at you, the best thing to do is dodge to the side, and start slashing at him. He can also reach his tentacles to the ground and hit you with them, if you see them go underground immediately start dodging. Be careful when fighting next to him as well, as he can grab you or hit you with his arms and start squeezing you. Rapidly press buttons to release yourself. His final attack is an electrical charge that follows you around after he sends it out of his tentacle.

Dodge just before it reaches you, and it should just go by you. He shouldn't be too tough, but he does have allot of health to deal with. The best thing to do is to wait until he attacks you with his charge or his electrical shocks, dodge out of the way, and then begin attacking. Only use throwing knives whenever you are at a distance. DT whenever possible to cause more damage. If you are attacking while in DT, he shouldn't be able to attack you, Finally, Cranky Bombs can be somewhat useful in this fight if your timing is done right. If you see him fly up into the air, DODGE as fast as possible until you are directly beneath him. If you are too slow he will hit you with an undodgeable energy blast, or several small energy blasts. 

Arius Argosax 
This boss can spit poison out of its mouth which can be really annoying.
He can also hit you with its long tail if you get to close to it. The best thing to do is to use throwing knives for the whole fight. When you DT gauge is full, go to the ground, and hold square to do the most damage.

This fight is really easy as long as you use the healing heart to stay healthy so that you can last out all of his lifebar. Just stay at one end of the canyon while shooting, until the beast gets close enough, then dodge to the other end and repeat.